Cortinovis A, Crippa A, Crippa M, Bosoni T, Moratti R
Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.
Minerva Cardioangiol. 1992 Sep;40(9):323-30.
The ESR is usually put in relationship: to the real density of the RBCs (erythrocytes) (difference between the RBC specific gravity and the plasma one), and to the resistance that the RBCs meet moving in a medium, which is due to the plasma viscosity and to the total external RBC surface. When the RBCs take shape of aggregates, their external surface is decreased and ESR increases. The most important plasma factor causing changes in ESR is the fibrinogen level followed by the plasma globulins and by the products arising from the tissue damage. The resistance that the RBCs meet moving in the plasma is well expressed by the measurement of the plasma-RBC viscosity considering that is inclusive of both factors that are the plasma viscosity and the external RBC surface. The plasma-RBC viscosity is the resultant of several factors: Fa = Fb - Fe - Fs - Fm, were: Fa is the resultant, Fb the attracting forces due to the proteic macromolecules, Fe the repulsing forces due the negative charges. Fs the repulsing forces due to the shear-stress, Fm the force which opposes itself against the surface tension of the aggregation; it depends on the RBC morphology and on the RBC rigidity. The ESR has been recently used like an index of the RBC aggregation. The Authors study the relationship between several hemorheological parameters and the ESR in infective and inflammatory processes.(ABSTRACT TRUNCATED AT 250 WORDS)
红细胞沉降率（ESR）通常与以下因素有关：红细胞（RBCs）的实际密度（红细胞比重与血浆比重之差），以及红细胞在介质中移动时所遇到的阻力，这是由血浆粘度和红细胞总外表面积决定的。当红细胞形成聚集体时，其外表面积减小，ESR增加。导致ESR变化的最重要血浆因子是纤维蛋白原水平，其次是血浆球蛋白和组织损伤产生的产物。考虑到血浆-红细胞粘度包含血浆粘度和红细胞外表面积这两个因素，通过测量血浆-红细胞粘度可以很好地表示红细胞在血浆中移动时所遇到的阻力。血浆-红细胞粘度是多种因素的结果：Fa = Fb - Fe - Fs - Fm，其中：Fa是合力，Fb是蛋白质大分子产生的吸引力，Fe是负电荷产生的排斥力，Fs是剪切应力产生的排斥力，Fm是抵抗聚集体表面张力的力；它取决于红细胞形态和红细胞刚性。ESR最近已被用作红细胞聚集的指标。作者研究了感染性和炎症性过程中几种血液流变学参数与ESR之间的关系。（摘要截断于250字）
