Obermiller Joseph F, Hodde Jason P, McAlexander Chad S, Kokini Klod, Badylak Stephen F
School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Med Sci Monit. 2004 Jan;10(1):PI1-5.
The suture holding capacity, suture retention strength, and burst strength of three biomaterials (Marlex), SIS, and PeriGuard) were evaluated to compare their performance characteristics in an ex vivo setting representing the immediate postoperative period.
MATERIAL/METHODS: A circular defect was created in the fascial tissue of the abdominal aponeurosis collected from normal dogs. Defects were repaired with either Marlex (polypropylene mesh), Periguard (bovine pericardium) or small intestinal submucosa (SIS) using 2-0 prolene and a 1.0-cm suture bite. The force required to induce failure at the repair site was recorded as the suture-holding capacity. Suture retention strength was calculated as the load distribution over the specimen cross-section in contact with the suture at the time of rupture. Burst strength of the raw materials was also measured.
The suture-holding capacity was 370.9+/-56.2 N for Marlex; 214.3+/-36.1 N for Periguard, and 287.9+/-34.3 N for SIS. The suture retention strengths were: Marlex, 413.4+/-59.7 N/mm2; Periguard, 97.0+/-20.1 N/mm2; and SIS, 106.9+/-12.7 N/mm2. The burst strength of Marlex, Periguard and SIS were 476.7+/-50.8 N, 432.12+/-82.1 N, and 433.6+/-79.5 N respectively.
All three materials provide adequate strength and suture-holding capacities to be of use in the repair of soft tissue defects.
评估了三种生物材料（Marlex、SIS和PeriGuard）的缝线夹持能力、缝线保留强度和破裂强度，以比较它们在代表术后即刻阶段的体外环境中的性能特征。
材料/方法：在从正常犬收集的腹直肌筋膜组织中创建圆形缺损。使用2-0普理灵缝线和1.0厘米的缝线咬距，用Marlex（聚丙烯网片）、Periguard（牛心包）或小肠黏膜下层（SIS）修复缺损。将修复部位诱导失败所需的力记录为缝线夹持能力。缝线保留强度计算为破裂时与缝线接触的标本横截面上的负荷分布。还测量了原材料的破裂强度。
Marlex的缝线夹持能力为370.9±56.2牛；Periguard为214.3±36.1牛，SIS为287.9±34.3牛。缝线保留强度分别为：Marlex，413.4±59.7牛/平方毫米；Periguard，97.0±20.1牛/平方毫米；SIS，106.9±12.7牛/平方毫米。Marlex、Periguard和SIS的破裂强度分别为476.7±50.8牛、432.12±82.1牛和433.6±79.5牛。
所有三种材料都具有足够的强度和缝线夹持能力，可用于修复软组织缺损。
