Li Xin, Guo Yuanyuan, Ziegler Kenneth R, Model Lynn S, Eghbalieh Sammy D D, Brenes Robert A, Kim Susun T, Shu Chang, Dardik Alan
Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
Ann Vasc Surg. 2011 May;25(4):561-8. doi: 10.1016/j.avsg.2010.11.007. Epub 2011 Jan 28.
Bovine pericardium (BP) is widely used in surgery and is commonly used as a patch after arteriotomy in cardiovascular surgery. BP patches have several advantages compared with prosthetic patches, including superior biocompatability, easy handling, less suture line bleeding, and possibly reduced rates of infection. These advantages of BP have led to its common use during carotid endarterectomy (CEA). However, long-term clinical results reported after CEA have suggested several issues that may be related to the patch, including restenosis, pseudoaneurysm formation, infection, fibrosis, calcification, and thrombosis. These complications may diminish the long-term efficacy of CEA and suggest potential areas for improvement of surgical patches. Understanding the mechanisms by which BP heals after patch angioplasty may lead to next generation tissue-engineered patches.
牛心包（BP）在外科手术中广泛应用，在心血管手术中动脉切开术后常用作补片。与人工补片相比，BP补片具有几个优点，包括卓越的生物相容性、易于操作、缝合线出血少以及可能降低的感染率。BP的这些优点使其在颈动脉内膜切除术（CEA）中得以普遍使用。然而，CEA术后报告的长期临床结果提示了一些可能与补片相关的问题，包括再狭窄、假性动脉瘤形成、感染、纤维化、钙化和血栓形成。这些并发症可能会降低CEA的长期疗效，并提示手术补片潜在的改进领域。了解BP在补片血管成形术后愈合的机制可能会带来下一代组织工程补片。
