Colditz I G, Woolaston R R, Lax J, Mortimer S I
CSIRO Division of Animal Health, Armidale NSW, Australia.
Parasite Immunol. 1992 Nov;14(6):587-94. doi: 10.1111/j.1365-3024.1992.tb00031.x.
The leakage of plasma into skin following injection of histamine, bradykinin, activated complement, platelet-activating factor and serotonin was measured in sheep bred for resistance or susceptibility to fleece rot and fly strike. Genetically susceptible sheep had significantly greater plasma leakage to activated complement than genetically resistant sheep, and for all mediators there was a trend for plasma leakage to be greater in susceptible sheep. Within each genotype there was also a tendency for plasma leakage to be positively correlated with fleece rot score. In a flock of sheep of different genetic background not selected for resistance or susceptibility to fleece rot and fly strike, positive phenotypic correlations were also noted between fleece rot and plasma leakage. Plasma leakage provides nutrition for the first instar larvae of Lucilia cuprina, the major cause of primary blowfly strike in Australia. Diminished leakage of plasma following release of endogenous permeability mediators may be one component of the mechanism that confers resistance in animals bred for resistance to fleece rot and fly strike.
在对羊毛腐烂和蝇蛆侵袭具有抗性或易感性的绵羊中，测量了注射组胺、缓激肽、活化补体、血小板活化因子和5-羟色胺后血浆渗入皮肤的情况。遗传易感性绵羊对活化补体的血浆渗漏明显大于遗传抗性绵羊，并且对于所有介质，易感性绵羊的血浆渗漏都有更大的趋势。在每个基因型中，血浆渗漏也有与羊毛腐烂评分呈正相关的趋势。在一群未针对羊毛腐烂和蝇蛆侵袭的抗性或易感性进行选择的不同遗传背景的绵羊中，也注意到羊毛腐烂与血浆渗漏之间存在正表型相关性。血浆渗漏为澳大利亚原发性蝇蛆侵袭的主要原因——铜绿蝇的一龄幼虫提供营养。内源性通透性介质释放后血浆渗漏减少可能是赋予对羊毛腐烂和蝇蛆侵袭具有抗性的动物抗性的机制的一个组成部分。
