Gustafsson M, Flood C, Jirholt P, Borén J
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, 413 45, Göteborg, Sweden.
Cell Mol Life Sci. 2004 Jan;61(1):4-9. doi: 10.1007/s00018-003-3262-x.
Atherosclerosis is a multifactorial disease whose pathogenesis is still unclear. Mounting evidence, however, supports the concept that subendothelial retention of apoB100-containing lipoproteins is the initiating event in atherogenesis. Subsequently, a series of biological responses to this retained material leads to specific molecular and cellular processes that promote lesion formation.
动脉粥样硬化是一种多因素疾病,其发病机制尚不清楚。然而,越来越多的证据支持这样一种观点,即含载脂蛋白B100的脂蛋白在内皮下的潴留是动脉粥样硬化发生的起始事件。随后,针对这种潴留物质的一系列生物学反应会引发特定的分子和细胞过程,从而促进病变形成。