Barbarich Nicole C, McConaha Claire W, Halmi Katherine A, Gendall Kelly, Sunday Suzanne R, Gaskill Jill, La Via Maria, Frank Guido K, Brooks Sarah, Plotnicov Katherine H, Kaye Walter H
Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Pittsburgh, Pennsylvania 15213, USA.
Int J Eat Disord. 2004 Jan;35(1):10-5. doi: 10.1002/eat.10235.
Selective serotonin reuptake inhibitor (SSRI) medication does not appear to be effective in ill, malnourished anorexia nervosa (AN) patients. However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects.
Twenty-six subjects with AN participated in a trial of fluoxetine. In a double-blind, placebo-controlled manner, subjects received either nutritional supplements or a nutritional placebo. The nutritional supplement included tryptophan (the precursor of serotonin), vitamins, minerals, and essential fatty acids believed to influence serotonin pathway function.
There was no significant difference in weight gain between subjects treated with fluoxetine plus nutritional supplements versus fluoxetine plus a nutritional placebo. Moreover, there were no significant differences between groups on mean changes in anxiety or obsessive and compulsive symptoms.
The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects.
选择性5-羟色胺再摄取抑制剂（SSRI）药物对患病且营养不良的神经性厌食症（AN）患者似乎无效。然而，它可能对体重恢复后的复发预防有效。本研究的目的是确定营养补充剂是否能增强氟西汀对体重过轻的AN患者的疗效。
26名AN患者参与了氟西汀试验。以双盲、安慰剂对照的方式，受试者接受营养补充剂或营养安慰剂。营养补充剂包括色氨酸（5-羟色胺的前体）、维生素、矿物质以及据信会影响5-羟色胺途径功能的必需脂肪酸。
接受氟西汀加营养补充剂治疗的受试者与接受氟西汀加营养安慰剂治疗的受试者在体重增加方面无显著差异。此外，两组在焦虑或强迫症状的平均变化上也无显著差异。
本研究结果表明，补充策略不能替代充足的营养，且对提高氟西汀对体重过轻的AN患者的疗效无效。
