Fennerty M Brian
Division of Gastroenterology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, PV-310, Portland, OR 97201-3098, USA.
Cleve Clin J Med. 2003 Nov;70 Suppl 5:S33-50. doi: 10.3949/ccjm.70.suppl_5.s33.
Complications of chronic gastroesophageal reflux disease (GERD) run the gamut from erosive esophagitis to esophageal cancer, but all are linked to repeated exposure of the esophagus to caustic gastric and duodenal acid. Progression from one complication to another is not clearly established across the GERD continuum, although there is a clear progression from the serious complication of Barrett's esophagus to esophageal adenocarcinoma. This review examines the range of complications that can arise from chronic GERD, underscoring the need to view heartburn as a symptom of a potentially serious condition.
慢性胃食管反流病（GERD）的并发症范围广泛，从糜烂性食管炎到食管癌，但所有这些都与食管反复接触腐蚀性的胃酸和十二指肠酸有关。尽管从巴雷特食管这一严重并发症到食管腺癌有明确的进展过程，但在整个GERD连续过程中，从一种并发症到另一种并发症的进展情况尚未明确确立。本综述探讨了慢性GERD可能引发的一系列并发症，强调了将烧心视为潜在严重疾病症状的必要性。
