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沉默的杀手:一例伴有糖尿病、代谢功能障碍相关脂肪性肝病和胃食管反流病的基底动脉血栓形成尸检病例

The Silent Killer: An Autopsy Case of Basilar Artery Thrombosis With Diabetes Mellitus, Metabolic Dysfunction-Associated Steatotic Liver Disease, and Gastroesophageal Reflux Disease.

作者信息

Izumi Rina, Hayashi Koji, Kawahara Ei, Suzuki Asuka, Nakaya Yuka, Hayashi Maho, Sato Mamiko, Kobayashi Yasutaka

机构信息

Department of Rehabilitation Medicine, Fukui General Hospital, Fukui, JPN.

Department of Pathology, Fukui General Hospital, Fukui, JPN.

出版信息

Cureus. 2025 May 8;17(5):e83701. doi: 10.7759/cureus.83701. eCollection 2025 May.

Abstract

We report a case of autopsy-confirmed basilar artery thrombosis in a 58-year-old male with a history of diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD), and gastroesophageal reflux disease (GERD). The patient presented with cardiopulmonary arrest while eating and died two hours after the initial collapse. Postmortem imaging could not identify a definitive cause of death. The autopsy revealed acute hemorrhagic infarcts in the brainstem, along with evidence of basilar artery thrombosis and severe arteriosclerosis. The presence of diabetes, MASLD, and GERD may have contributed to the development of arteriosclerosis and increased the risk of cardiovascular events. This case highlights the complex interplay between seemingly unrelated medical conditions and their potential to contribute to sudden and unexpected death. While diabetes and MASLD are often referred to as "silent killers," in this case, basilar artery thrombosis acted as the final "silent killer" for the patient. The autopsy revealed a complex web of silent killers, ultimately concluding that basilar artery embolism was the cause of death.

摘要

我们报告一例经尸检确诊的基底动脉血栓形成病例,患者为一名58岁男性,有糖尿病、代谢功能障碍相关脂肪性肝病(MASLD)和胃食管反流病(GERD)病史。患者在进食时出现心肺骤停,初始晕倒两小时后死亡。尸检成像未能确定明确的死因。尸检显示脑干有急性出血性梗死,同时存在基底动脉血栓形成和严重动脉硬化的证据。糖尿病、MASLD和GERD的存在可能促成了动脉硬化的发展,并增加了心血管事件的风险。该病例凸显了看似不相关的医疗状况之间的复杂相互作用及其导致突然和意外死亡的可能性。虽然糖尿病和MASLD常被称为“沉默杀手”,但在本病例中,基底动脉血栓形成成为了患者最后的“沉默杀手”。尸检揭示了一个由沉默杀手构成的复杂网络,最终判定基底动脉栓塞为死因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d552/12144561/c2045345e459/cureus-0017-00000083701-i01.jpg

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