希腊社区获得性尿路感染大肠杆菌菌株中的喹诺酮耐药性。
Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.
作者信息
Chaniotaki S, Giakouppi P, Tzouvelekis L S, Panagiotakos D, Kozanitou M, Petrikkos G, Avlami A, Vatopoulos A C
机构信息
Department of Microbiology, National School of Public Health, 196 Alexandras Avenue, Athens 115 21, Greece.
出版信息
Clin Microbiol Infect. 2004 Jan;10(1):75-8. doi: 10.1111/j.1469-0691.2004.00807.x.
Susceptibility data for 10 049 Escherichia coli isolates derived from community-acquired urinary tract infections in Greece during the period January 2000 to June 2002 indicated 8.1% resistance to nalidixic acid and 36% resistance to ciprofloxacin. In a sample of 170 E. coli isolates, mutations in gyrA (25 isolates) and parC (15 isolates) were consistent with the levels of resistance to quinolones. Previous exposure to quinolones and underlying chronic disease were independent risk factors for infection by quinolone-resistant E. coli strains.
2000年1月至2002年6月期间，从希腊社区获得性尿路感染中分离出的10049株大肠杆菌的药敏数据显示，对萘啶酸的耐药率为8.1%，对环丙沙星的耐药率为36%。在170株大肠杆菌分离株的样本中，gyrA（25株）和parC（15株）的突变与喹诺酮类药物的耐药水平一致。先前接触喹诺酮类药物和潜在的慢性疾病是耐喹诺酮类大肠杆菌菌株感染的独立危险因素。
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