与两种非飞行哺乳动物相比，小棕蝠（Myotis lucifugus）自由基产生减少与寿命极长。

Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals.

作者信息

Brunet-Rossinni Anja K

机构信息

Department of Ecology, Evolution and Behavior, James Ford Bell Museum of Natural History, University of Minnesota, Saint Paul, MN 55108, USA.

出版信息

Mech Ageing Dev. 2004 Jan;125(1):11-20. doi: 10.1016/j.mad.2003.09.003.

DOI:10.1016/j.mad.2003.09.003

PMID:14706233

Abstract

The extended longevity of bats, despite their high metabolic rate, may provide insight to patterns and mechanisms of aging. Here I test predictions of the free radical or oxidative stress theory of aging as an explanation for differences in lifespan between the little brown bat, Myotis lucifugus (maximum lifespan potential MLSP=34 years), the short-tailed shrew, Blarina brevicauda (MLSP=2 years), and the white-footed mouse, Peromyscus leucopus (MLSP=8 years) by comparing whole-organism oxygen consumption, hydrogen peroxide production, and superoxide dismutase activity in heart, kidney, and brain tissue. Mitochondria from M. lucifugus produced half to one-third the amount of hydrogen peroxide per unit of oxygen consumed compared to mitochondria from B. brevicauda and P. leucopus, respectively. Superoxide dismutase (SOD) activity did not differ among the three species. These results are similar to those found for birds, which like bats have high metabolic rates and extended longevities, and provide support for the free radical theory of aging as an at least partial explanation for the extreme longevity of bats.

摘要

尽管蝙蝠的代谢率很高，但它们的长寿可能为衰老的模式和机制提供见解。在这里，我通过比较小棕蝠（Myotis lucifugus，最大寿命潜力MLSP = 34年）、短尾鼩鼱（Blarina brevicauda，MLSP = 2年）和白足鼠（Peromyscus leucopus，MLSP = 8年）的全生物体耗氧量、过氧化氢产生量以及心脏、肾脏和脑组织中的超氧化物歧化酶活性，来检验衰老的自由基或氧化应激理论的预测，以解释它们寿命的差异。与分别来自短尾鼩鼱和白足鼠的线粒体相比，小棕蝠的线粒体每消耗单位氧气产生的过氧化氢量只有它们的一半到三分之一。超氧化物歧化酶（SOD）活性在这三个物种之间没有差异。这些结果与在鸟类中发现的结果相似，鸟类和蝙蝠一样具有高代谢率和较长的寿命，这为衰老的自由基理论提供了支持，即该理论至少可以部分解释蝙蝠的超长寿命。