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对57例连续性食管穿孔患者的个体化管理。

Personal management of 57 consecutive patients with esophageal perforation.

作者信息

Gupta Narendar Mohan, Kaman Lileswar

机构信息

Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

出版信息

Am J Surg. 2004 Jan;187(1):58-63. doi: 10.1016/j.amjsurg.2002.11.004.

DOI:10.1016/j.amjsurg.2002.11.004
PMID:14706587
Abstract

BACKGROUND

Esophageal perforation is a surgical emergency associated with high morbidity and mortality. There is no consensus regarding the appropriate management of this life-threatening condition.

METHODS

A retrospective review was made of 57 patients with esophageal perforations treated at the Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India, between September 1986 and December 2001.

RESULTS

Forty-four (77%) perforations were due to iatrogenic causes, spontaneous perforations occurred in 6 patients (11%). Foreign body ingestion caused perforation in 4 (7%), followed by blunt trauma in 2 (4%) and caustic injury in 1 patient. A total of 6 (11%) patients had cervical injury, 49 (86%) patients had thoracic, and 1 patient had abdominal esophageal injury. Thirty-three (58%) patients underwent emergency esophagectomy, 4 (7%) patients underwent primary repair, and 4 patients (7%) underwent drainage alone, whereas 16 (28%) patients were managed by nonoperative treatment. Using these treatment principles, we achieved 86% survival rate for all patients. Eight (14%) patients died. Spontaneous perforation had the highest mortality (67%).

CONCLUSIONS

Esophageal perforation needs aggressive treatment. The treatment depends mainly on two factors: perforation in a healthy esophagus, and perforation with a preexisting underlying intrinsic esophageal disease causing distal obstruction. Esophageal perforation associated with stenotic lesions (benign or malignant) needs esophageal extirpation. Perforation in a healthy esophagus should be treated by primary closure if encountered early. Nonoperative conservative treatment is appropriate when esophageal perforation is encountered late.

摘要

背景

食管穿孔是一种外科急症,其发病率和死亡率都很高。对于这种危及生命的疾病,目前尚无统一的合适治疗方案。

方法

对1986年9月至2001年12月间在印度昌迪加尔医学教育与研究研究生院外科接受治疗的57例食管穿孔患者进行回顾性研究。

结果

44例(77%)穿孔是由医源性原因引起,6例(11%)为自发性穿孔。4例(7%)因异物吞食导致穿孔,2例(4%)因钝性创伤,1例因腐蚀性损伤。共有6例(11%)患者为颈部损伤,49例(86%)为胸部损伤,1例为腹部食管损伤。33例(58%)患者接受了急诊食管切除术,4例(7%)患者进行了一期修复,4例(7%)患者仅接受了引流,而16例(28%)患者采用非手术治疗。采用这些治疗原则,所有患者的生存率达到了86%。8例(14%)患者死亡。自发性穿孔的死亡率最高(67%)。

结论

食管穿孔需要积极治疗。治疗主要取决于两个因素:健康食管的穿孔,以及存在潜在内在食管疾病导致远端梗阻的穿孔。与狭窄病变(良性或恶性)相关的食管穿孔需要进行食管切除。如果早期发现,健康食管的穿孔应通过一期缝合进行治疗。如果食管穿孔发现较晚,非手术保守治疗是合适的。

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