鸡胚中前庭眼电路的发育。

The development of vestibulo-ocular circuitry in the chicken embryo.

作者信息

Glover Joel C

机构信息

Department of Physiology, University of Oslo, PB 1103 Blindern, 0317 Oslo, Norway.

出版信息

J Physiol Paris. 2003 Jan;97(1):17-25. doi: 10.1016/j.jphysparis.2003.10.003.

DOI:10.1016/j.jphysparis.2003.10.003

PMID:14706687

Abstract

This article reviews studies of the organization and development of the vestibulo-ocular reflex arc in the chicken embryo. It summarizes some of the principal features that characterize the development of this circuit, including the gradual clustering of motoneurons in the oculomotor nucleus into functionally identifiable motoneuron pools, the patterning of vestibular projection neurons into coherent clusters with specific axonal trajectories and terminations onto the oculomotor motoneuron pools, the reverse order of synapse formation during development (motoneuron to muscle, then vestibular projection neuron to motoneuron), and the selectivity of initial synaptic termination at both the ultimate and penultimate relays within the reflex arc. Reference to studies in other vertebrate species is made to provide a comparative context, and potential mechanisms are discussed that may contribute to the underlying synaptic specificity in this circuit.

摘要

本文综述了鸡胚前庭眼反射弧的组织和发育研究。它总结了该神经回路发育的一些主要特征，包括动眼神经核中的运动神经元逐渐聚集成功能上可识别的运动神经元池，前庭投射神经元形成具有特定轴突轨迹并终止于动眼神经运动神经元池的连贯簇，发育过程中突触形成的反向顺序（运动神经元到肌肉，然后前庭投射神经元到运动神经元），以及反射弧内最终和倒数第二级中继处初始突触终止的选择性。文中还提及了其他脊椎动物物种的研究以提供比较背景，并讨论了可能导致该神经回路潜在突触特异性的潜在机制。