Lee Haeryun, Adler Paul N
Department of Biology and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA.
Mech Dev. 2004 Jan;121(1):37-49. doi: 10.1016/j.mod.2003.11.002.
The Drosophila wing is covered by an array of distally pointing hairs. This tissue planar polarity is regulated by the frizzled pathway. We have found that the function of the grainy head transcription factor is essential for the function of the frizzled pathway. grainy head mutant cells fail to localize planar polarity proteins at either the proximal or distal sides of wing cells and produce multiple hairs of abnormal polarity. Levels of the Starry night protein are strongly reduced in grainy head mutants in both larval wing discs and pupal wings, which is sufficient to account for much of the polarity phenotype. In addition, we found that grh has frizzled pathway independent functions during the development of the adult cuticle.
果蝇翅膀覆盖着一系列指向远端的刚毛。这种组织平面极性由卷曲蛋白通路调节。我们发现颗粒头转录因子的功能对于卷曲蛋白通路的功能至关重要。颗粒头突变细胞无法在翅细胞的近端或远端定位平面极性蛋白，并产生多个极性异常的刚毛。在幼虫翅盘和蛹翅中，颗粒头突变体中星夜蛋白的水平大幅降低，这足以解释大部分极性表型。此外，我们发现在成虫表皮发育过程中，颗粒头转录因子具有独立于卷曲蛋白通路的功能。
