Guilleminault C, Stoohs R, Clerk A, Simmons J, Labanowski M
Stanford Sleep Research Center, Palo Alto, California 94304.
Sleep. 1992 Dec;15(6 Suppl):S13-6.
Some patients with excessive daytime sleepiness who do not present the features of obstructive sleep apnea syndrome (OSAS) present a sleep fragmentation due to transient alpha EEG arousals lasting between three and 14 seconds. These transient EEG arousals are related to an abnormal amount of breathing effort, indicated by peak inspiratory esophageal pressure (Pes) nadir. In the studied population, these increased efforts were associated with snoring. Usage of nasal CPAP, titrated on Pes nadir values, for several weeks eliminated subjective daytime sleepiness and improved Multiple Sleep Latency Test scores from baseline evaluations. Patients suspected of CNS hypersomnia should be asked about continuous snoring, and their clinical evaluation should include a good review of maxillo-mandibular and upper airway anatomy.
一些白天过度嗜睡但不表现出阻塞性睡眠呼吸暂停综合征（OSAS）特征的患者，由于持续3至14秒的短暂α脑电图觉醒而出现睡眠片段化。这些短暂的脑电图觉醒与异常的呼吸努力量有关，吸气峰值食管压力（Pes）最低点可表明这一点。在研究人群中，这些增加的努力与打鼾有关。根据Pes最低点值进行滴定的鼻持续气道正压通气（CPAP）使用数周后，消除了主观白天嗜睡，并使多次睡眠潜伏期测试得分从基线评估有所改善。怀疑患有中枢神经系统性失眠的患者应询问是否持续打鼾，其临床评估应包括对上颌下颌和上气道解剖结构的详细检查。
