Jabłońska J, Brzeziński J
Zakładu Toksykologii Instytutu Biofarmacji Akademii Medycznej w Warszawie.
Rocz Panstw Zakl Hig. 1992;43(2):151-5.
The influence of acute (50% and 20% LD50), subacute (10% LB50) and 12-week (5% LD50) intoxication with carbaryl on NA level in rat brain was investigated. The level of NA was decreased by about 40% of the control level (p > 0.001) after acute and subacute intoxication. In the subchronic study (5% LD50 for 12 weeks) carbaryl significantly decreased the NA level (p < 0.001), but after 2-week intoxication only. During the next weeks NA content remained on control level (p > 0.05). These results indicate that carbaryl causes noradrenergic alterations in rat brain, which may lead to neurotoxic action.
研究了急性（50%和20%致死剂量50）、亚急性（10%致死剂量50）和12周（5%致死剂量50）西维因中毒对大鼠脑内去甲肾上腺素（NA）水平的影响。急性和亚急性中毒后，NA水平降低至对照水平的约40%（p>0.001）。在亚慢性研究中（12周给予5%致死剂量50），西维因显著降低了NA水平（p<0.001），但仅在中毒2周后。在接下来的几周内，NA含量维持在对照水平（p>0.05）。这些结果表明，西维因可引起大鼠脑内去甲肾上腺素能改变，这可能导致神经毒性作用。
