Gasljević Gorana, Lamovec Janez
Department of Pathology, Institute of Oncology, Ljubljana, Slovenia.
Pathol Res Pract. 2003;199(11):745-9. doi: 10.1078/0344-0338-00491.
We report on a case of a 40-year-old male patient who underwent a gastrectomy because of a biopsy-proven large B-cell lymphoma of the stomach. On surgery, a nodule in the spleen also was noted. Grossly and microscopically, the two lesions were different: the tumor of the stomach appeared white-gray on the cut surface and was a centroblastic variant of diffuse large B-cell lymphoma. Histologically, one perigastric lymph node was involved. Grossly, the splenic nodule was gray-yellow and had a histological appearance of an inflammatory myofibroblastic tumor (IMT). The association between malignant tumor and IMT is rare. In such an association, the latter lesion most often has been reported in the spleen. As EBV may be involved in the genesis of both lymphoma and IMT, we tested both lesions for its presence using in situ hybridization, but the tests were negative. It remains to be verified whether the association between lymphoma and IMT is more than fortuitous.
我们报告了一例40岁男性患者，该患者因活检证实为胃大B细胞淋巴瘤而接受了胃切除术。手术中，还发现脾脏有一个结节。大体和显微镜下，这两个病变不同：胃肿瘤切面呈灰白色，是弥漫性大B细胞淋巴瘤的中心母细胞变异型。组织学上，一个胃周淋巴结受累。大体上，脾脏结节为灰黄色，组织学表现为炎性肌成纤维细胞瘤（IMT）。恶性肿瘤与IMT之间的关联很少见。在这种关联中，后一种病变最常报道于脾脏。由于EBV可能参与淋巴瘤和IMT的发生，我们使用原位杂交检测了这两个病变中是否存在EBV，但检测结果为阴性。淋巴瘤与IMT之间的关联是否不仅仅是偶然的，仍有待证实。
