严重二甲双胍相关性乳酸性酸中毒患者意外存活
Unexpected survival from severe metformin-associated lactic acidosis.
作者信息
Schure P J C M, de Gooijer A, van Zanten A R H
机构信息
Department of Internal Medicine and Intensive Care, Gelderse Vallei Hospital, PO Box 9025, 6710 HN Ede, The Netherlands.
出版信息
Neth J Med. 2003 Oct;61(10):331-3.
Lactic acidosis is a recognised complication of the antihyperglycaemic biguanide agent metformin, especially in patients with renal failure. We report a case of severe lactic acidosis and hypothermia due to metformin treatment and renal impairment. The favourable outcome despite extremely unfavourable clinical signs and symptoms for survival after admission and initial treatment was unexpected. Specific aspects of the clinical course are addressed.
乳酸酸中毒是抗高血糖双胍类药物二甲双胍公认的一种并发症，尤其在肾衰竭患者中。我们报告一例因二甲双胍治疗和肾功能损害导致的严重乳酸酸中毒和体温过低病例。尽管入院及初始治疗后出现了极其不利于生存的临床症状和体征，但最终预后良好，这令人意外。本文探讨了该临床病程的具体情况。
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