Steinbach W J, Perfect J R
Department of Pediatrics, Duke University, Durham, NC 27710, USA.
J Chemother. 2003 Nov;15 Suppl 2:16-27. doi: 10.1179/joc.2003.15.Supplement-2.16.
Scedosporium species are now increasingly isolated from immunocompromised and immunocompetent patients. Unfortunately, Scedosporium species infections are generally resistant to amphotericin B, and S. prolificans strains are particularly resistant to presently-available antifungal agents. Here we review the microbiology, expanding epidemiology, numerous clinical presentations, and diagnostic tools available for Scedosporium species infections. Finally, we detail the available in vitro, animal model, and clinical data on the treatment of Scedosporium species infections with special emphasis on the role of newer antifungal therapies for these recalcitrant infections.
目前，多育赛多孢菌越来越多地从免疫功能低下和免疫功能正常的患者中分离出来。不幸的是，多育赛多孢菌感染通常对两性霉素B耐药，而多育赛多孢菌菌株对目前可用的抗真菌药物尤其耐药。在此，我们综述了多育赛多孢菌的微生物学、不断扩大的流行病学、众多临床表现以及用于多育赛多孢菌感染的诊断工具。最后，我们详细介绍了有关多育赛多孢菌感染治疗的现有体外、动物模型和临床数据，特别强调了新型抗真菌疗法在这些难治性感染中的作用。
