Toida Makoto, Watanabe Fumio, Goto Kazumi, Shibata Toshiyuki
Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu, Japan.
J Clin Laser Med Surg. 2003 Dec;21(6):363-7. doi: 10.1089/104454703322650176.
The aim of this study was to evaluate the usefulness of low-level laser therapy (LLLT) for the control of painful stomatitis in patients with hand-foot-and-mouth disease (HFMD).
LLLT has been successfully applied to various painful oral mucosal diseases, although there have been few reports on LLLT for HFMD patients.
Through a randomized double-blind placebo controlled trial, the painful period of HFMD stomatitis was compared between the LLLT group (n=11) and the placebo LLLT one (n=9), which had similar clinical backgrounds. The LLLT parameters supplied were as follows: wavelength of 830 nm, power of 30 mW, frequency of 30 Hz, and energy output of 1.1 J/cm2. Acceptability and safety of the treatment were also evaluated.
The painful period was shorter in the LLLT group (4.0 +/- 1.3 days) than in the placebo LLLT one (6.7 +/- 1.6 days) with a statistically significant difference (p<0.005). The treatment was judged acceptable for 90.0% (18 of 20) of patients. No adverse events were observed in any cases.
LLLT is a useful method to control HFMD stomatitis by shortening the painful period, with its high acceptability and lack of adverse events.
本研究旨在评估低强度激光疗法（LLLT）对手足口病（HFMD）患者疼痛性口腔炎的控制效果。
LLLT已成功应用于各种疼痛性口腔黏膜疾病，尽管关于HFMD患者的LLLT报道较少。
通过随机双盲安慰剂对照试验，比较了临床背景相似的LLLT组（n = 11）和安慰剂LLLT组（n = 9）HFMD口腔炎的疼痛期。提供的LLLT参数如下：波长830 nm，功率30 mW，频率30 Hz，能量输出1.1 J/cm²。还评估了治疗的可接受性和安全性。
LLLT组的疼痛期（4.0±1.3天）比安慰剂LLLT组（6.7±1.6天）短，差异有统计学意义（p<0.005）。90.0%（20例中的18例）的患者认为该治疗可接受。未观察到任何不良事件。
LLLT是一种通过缩短疼痛期来控制HFMD口腔炎的有效方法，具有高可接受性且无不良事件。
