Lee Kyung Sun, Kim So Young, Han Jeong Hee, Kim Yun Ah, Cao Chunhua, Kim Sung Zoo, Cho Kyung Woo, Kim Suhn Hee
Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju 561-180, Korea.
Exp Biol Med (Maywood). 2004 Jan;229(1):65-71. doi: 10.1177/153537020422900108.
This study investigated whether high-salt intake influences atrial natriuretic peptide (ANP) system, atrial content, and release rate of ANP as well as receptor density in the kidney were measured in salt intake rats. Male Sprague-Dawley rats received either 0.9% or 2% salt in their drinking water for 10 days. The stretch-induced ANP secretion from isolated perfused non-beating left atria was accentuated, and the production of cGMP by ANP in renal cortical tissue membranes were pronounced in rats exposed to 0.9% salt for 10 days but not in rats exposed to 2% salt. The levels of ANP receptor density and expression in renal cortex were decreased in 2% salt intake rats but not in 0.9% salt intake rats. No significant differences in atrial and plasma concentrations of ANP and water balance were observed in both salt intakes. Therefore, these results suggest that atrial ANP secretion and its binding sites in the kidney may respond differently to ingested salt concentrations in rats.
本研究调查了高盐摄入是否会影响心房利钠肽（ANP）系统、心房利钠肽的心房含量、释放速率以及盐摄入大鼠肾脏中的受体密度。雄性Sprague-Dawley大鼠在饮水中分别摄入0.9%或2%的盐，持续10天。在接受0.9%盐处理10天的大鼠中，离体灌注的非搏动左心房拉伸诱导的ANP分泌增强，且肾皮质组织膜中ANP产生的cGMP明显增加，但在接受2%盐处理的大鼠中则不然。摄入2%盐的大鼠肾皮质中ANP受体密度和表达水平降低，而摄入0.9%盐的大鼠则未出现这种情况。两种盐摄入量下，心房和血浆中ANP浓度及水平衡均未观察到显著差异。因此，这些结果表明，大鼠心房ANP分泌及其在肾脏中的结合位点对摄入盐浓度的反应可能不同。
