垂体疾病中的抗α-烯醇化酶抗体。

Anti-alpha-enolase antibodies in pituitary disease.

作者信息

Tanaka Susumu, Tatsumi Ke-Ita, Takano Toru, Murakami Yoshio, Takao Toshihiro, Yamakita Noriyoshi, Tahara Shigeyuki, Teramoto Akira, Hashimoto Kozo, Kato Yuzuru, Amino Nobuyuki

机构信息

Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka, Japan.

出版信息

Endocr J. 2003 Dec;50(6):697-702. doi: 10.1507/endocrj.50.697.

DOI:10.1507/endocrj.50.697

PMID:14709840

Abstract

A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.

摘要

一项先前的研究报告称，淋巴细胞性垂体炎患者中α-烯醇化酶自身抗体的患病率很高，并且这些抗体能有效地区分淋巴细胞性垂体炎和垂体肿瘤。为了证实这一点，我们检测了淋巴细胞性垂体炎患者（n = 17）、垂体无功能腺瘤患者（n = 13）、其他垂体疾病患者（n = 17）和其他自身免疫性疾病患者（n = 30）体内的α-烯醇化酶自身抗体，并与健康对照者（n = 46）进行比较。自身抗体的检出率分别为41.2%、46.2%、23.5%、20.0%和4.3%。我们的研究结果表明，检测抗α-烯醇化酶抗体并不适用于淋巴细胞性垂体炎的特异性诊断。