Lerner Aaron, Sobolevskaia Polina, Churilov Leonid, Shoenfeld Yehuda
Chaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer, Israel.
Saint Petersburg State University, St. Petersburg, Russia.
J Transl Autoimmun. 2021 Jun 16;4:100109. doi: 10.1016/j.jtauto.2021.100109. eCollection 2021.
Celiac disease is a life-long intestinal autoimmune disease, characterized by the gluten intolerance and chronic enteric inflammation. Traditionally presented by intestinal manifestations, however, a shift toward extra intestinal presentation is taking place. One of the affected organs is the nervous systems presented by neuropsychiatric manifestations, hence the mechanism and pathways are not clear. The presence of neuronal and alpha-enolases and their corresponding antibodies were noticed in the mucosa and serum of celiac disease patients, as well as in other various autoimmune diseases with psycho-neurological manifestations. The aims of the present review are to screen the literature on different isoforms of enolase, mainly alpha enolase, and their specific antibodies and to suggest their potential pathophysiological mechanisms relaying the enolases to intestinal or extraintestinal celiac disease manifestations. The shared aspects between the enolases and celiac disease and the cross-talks between alpha-enolase and tissue transglutaminase suggest new potential pathophysiological mechanisms that might drive celiac disease evolvement.
乳糜泻是一种终身性肠道自身免疫性疾病，其特征为麸质不耐受和慢性肠道炎症。传统上以肠道表现为主，但目前正出现向肠道外表现转变的趋势。受影响的器官之一是神经系统，表现为神经精神症状，但其机制和途径尚不清楚。在乳糜泻患者的黏膜和血清中，以及在其他伴有精神神经症状的各种自身免疫性疾病中，均发现了神经元烯醇化酶和α-烯醇化酶及其相应抗体。本综述的目的是筛选有关烯醇化酶不同同工型（主要是α-烯醇化酶）及其特异性抗体的文献，并提出它们将烯醇化酶与肠道或肠道外乳糜泻表现相关联的潜在病理生理机制。烯醇化酶与乳糜泻之间的共同方面以及α-烯醇化酶与组织转谷氨酰胺酶之间的相互作用提示了可能驱动乳糜泻进展的新的潜在病理生理机制。
