Kaname Mamoru, Yoshinaga Kazuo, Arakawa Yasushi, Yoshifuji Shigeyuki
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi Ho-3, Kanazawa 920-1181, Japan.
Chem Pharm Bull (Tokyo). 2004 Jan;52(1):160-2. doi: 10.1248/cpb.52.160.
The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels-Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.
六氢哒嗪-3-膦酸（哌嗪-3-膦酸）的合成是通过杂环狄尔斯-阿尔德反应，然后进行路易斯酸催化的膦酰化反应来完成的。这一两步过程被改进为一锅法反应。
