De Graaf R M, Visscher J, Schwartz A W
Evolutionary Biology Research Group, Faculty of Science, University of Nijmegen, Nijmegen, The Netherlands.
Orig Life Evol Biosph. 1998 Jun;28(3):271-82. doi: 10.1023/a:1006543225618.
Phosphonoacetaldehyde (PAL), a phosphonic acid analogue of glycolaldehyde phosphate, reacts in the presence of formaldehyde under mildly basic conditions to produce several new products. The reaction proceeds in two stages: a fast aldol condensation of formaldehyde with PAL, and a slower reaction to produce products containing two phosphonic acid groups. We report on the derivatization, isolation by means of HPLC and characterization of these compounds. One of the products is of potential interest as a building block for a prebiotic informational polymer.
膦酰乙醛（PAL）是磷酸乙醇醛的膦酸类似物，在甲醛存在下于弱碱性条件下反应生成几种新产物。该反应分两个阶段进行：甲醛与PAL的快速羟醛缩合，以及生成含两个膦酸基团产物的较慢反应。我们报告了这些化合物的衍生化、通过高效液相色谱法进行分离及表征。其中一种产物作为益生元信息聚合物的构建单元可能具有潜在价值。
