Pressman Eva K, Cavanaugh Judith L, Mingione Matthew, Norkus Edward P, Woods James R
Division of Maternal Fetal Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Am J Obstet Gynecol. 2003 Dec;189(6):1720-5. doi: 10.1016/s0002-9378(03)00858-5.
We sought to determine whether vitamins C and E could be delivered to the fetal-placental unit through maternal oral supplementation.
In a randomized, double-blind study, 20 women received a daily prenatal vitamin with or without 400 IU of vitamin E and 500 mg of vitamin C, starting at 35 weeks' gestation. At randomization, a nutritional questionnaire, plasma vitamin C and E and red blood cell (RBC) vitamin E levels were determined. At delivery, concentrations of maternal and fetal plasma vitamin C and E, maternal and fetal RBC vitamin E, amniotic fluid vitamin C, and chorioamnion vitamin E and tensile strength were determined.
Maternal plasma vitamin E levels increased in the supplemented women but not in the control subjects. No changes in maternal vitamin C levels were noted. Maternal plasma vitamin C concentrations at delivery correlated closely with amniotic fluid vitamin C levels. Similarly, maternal plasma vitamin E levels at delivery correlated with the chorioamnion concentration of vitamin E.
Maternal plasma vitamin E levels are increased by oral supplementation. Maternal plasma vitamin C and E concentrations correlate with the concentration of vitamin C in the amniotic fluid and vitamin E in the chorioamnion, respectively.
我们试图确定维生素C和维生素E是否可以通过母体口服补充剂输送到胎儿-胎盘单位。
在一项随机双盲研究中，20名女性从妊娠35周开始每天接受含或不含400国际单位维生素E和500毫克维生素C的产前维生素。随机分组时，确定营养问卷、血浆维生素C和E以及红细胞（RBC）维生素E水平。分娩时，测定母体和胎儿血浆维生素C和E的浓度、母体和胎儿红细胞维生素E、羊水维生素C以及绒毛膜维生素E和抗张强度。
补充组女性的母体血浆维生素E水平升高，而对照组未升高。母体维生素C水平无变化。分娩时母体血浆维生素C浓度与羊水维生素C水平密切相关。同样，分娩时母体血浆维生素E水平与绒毛膜维生素E浓度相关。
口服补充剂可提高母体血浆维生素E水平。母体血浆维生素C和E浓度分别与羊水中维生素C浓度和绒毛膜中维生素E浓度相关。
