Hemostatic effects of ephedrine.

The effects of ephedrine on coagulation and on fibrinolysis were studied in six healthy volunteers. Six volunteers, matched by age and sex, served as untreated controls. Ephedrine was found to significantly prolong mean bleeding time by 2 minutes. Ephedrine has been proposed to activate fibrinolysis, but we found no increased tPA activity. The platelet count, APTT, factor VIII and von Willebrand factor remained constant. In an in vitro study ephedrine was found to inhibit platelet aggregation induced by adrenaline and, to some extent, also by ADP. The inhibition was competitive and not mediated via beta 2 adrenoceptor stimulation. It is concluded that there are hemostatic effects of ephedrine and that these may be of clinical relevance, the drug being very commonly used in connection with procedures where blood loss as well as venous thromboembolism are considerable problems.