Siegbahn A, Ruusuvaara L
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
Thromb Haemost. 1988 Dec 22;60(3):361-4.
Basal t-PA antigen concentration, PAI-I activity and fibrinolytic capacity was studied in plasma from 20 healthy teenager girls (age 15.9 +/- 1.3 years) and two groups of older healthy volunteers, consisting of 17 women (age 32 +/- 8 years, group 1) and 35 men (age 34 +/- 8 years, group 2). Basal t-PA antigen concentrations in plasma were found to be highly age-dependent with higher values with increasing age. The teenager girls had significantly lower values compared with the two groups of elderly volunteers. PAI-I levels were significantly higher in plasma from the teenager girls and the fibrinolytic capacity after 15 min of venous occlusion was significantly lower. In this study we also determined the effect of low-dose oral contraceptives (OC) on coagulation and fibrinolysis in the teenager group. Each teenager served as her own control with samples drawn before and on OC after 4 months of use. The coagulation parameters, factor VIII activity, AT III, Protein C and platelet counts were all within reference values before and on OC. The fibrinolytic activity in plasma after venous occlusion (15 min) increased significantly when the teenagers had used OC for 4 months. This phenomenon was explained by significantly decreased PAI levels and also by significantly increased t-PA antigen release from the vessel wall after venous occlusion.
对20名健康青少年女孩（年龄15.9±1.3岁）以及两组年龄较大的健康志愿者（一组为17名女性，年龄32±8岁，第1组；另一组为35名男性，年龄34±8岁，第2组）血浆中的基础组织型纤溶酶原激活剂（t-PA）抗原浓度、纤溶酶原激活物抑制物-1（PAI-1）活性及纤溶能力进行了研究。结果发现，血浆中的基础t-PA抗原浓度与年龄高度相关，随着年龄增长其值升高。青少年女孩的值显著低于两组老年志愿者。青少年女孩血浆中的PAI-1水平显著更高，静脉闭塞15分钟后的纤溶能力显著更低。在本研究中，我们还测定了低剂量口服避孕药（OC）对青少年组凝血和纤溶的影响。每位青少年作为自身对照，在使用OC前及使用4个月后采集样本。凝血参数、因子VIII活性、抗凝血酶III（AT III）、蛋白C及血小板计数在使用OC前后均在参考值范围内。青少年使用OC 4个月后，静脉闭塞（15分钟）后血浆中的纤溶活性显著增加。这一现象的原因是PAI水平显著降低，以及静脉闭塞后血管壁释放的t-PA抗原显著增加。
