Moiin Ali
Wayne State University, Troy, Michigan, USA.
J Drugs Dermatol. 2003 Dec;2(6):637-9.
Molluscum contagiosum, a viral disease of the skin, manifests as a smooth-surfaced, firm, and spherical papule with umbilication of the vertex. It commonly presents as multiple lesions, which may be extensive in immunocompromised patients, and may mimic cutaneous tumors in HIV co-infected patients. Infection usually persists for 6 months to 5 years before resolving naturally. Among immune-impaired persons with HIV infection is generally more persistent. To date, single and combination therapies for such patients have been unsatisfactory. Recent observations from a dermatology practice in which 6 patients with HIV and molluscum contagiosum were treated with 5-aminolevulinic acid (Levulan Kerastick) in conjunction with photodynamic therapy suggest clinical benefits; i.e., substantial reduction in lesional count and severity. Additional research is mandated.
传染性软疣是一种皮肤病毒性疾病，表现为表面光滑、质地坚硬的球形丘疹，顶端有脐凹。通常表现为多个损害，在免疫功能低下的患者中可能广泛存在，在合并感染HIV的患者中可能类似皮肤肿瘤。感染通常在自然消退前持续6个月至5年。在免疫受损的HIV感染者中，感染通常更持久。迄今为止，针对此类患者的单一疗法和联合疗法都不尽人意。最近一家皮肤科诊所的观察结果显示，6例合并HIV和传染性软疣的患者接受5-氨基酮戊酸（Levulan Kerastick）联合光动力疗法治疗后有临床获益，即皮损数量和严重程度大幅降低。因此需要进一步研究。
