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艾滋病患者中高效抗逆转录病毒疗法(HAART)治疗播散性传染性软疣的疗效

Resolution of disseminated molluscum contagiosum with Highly Active Anti-Retroviral Therapy (HAART) in patients with AIDS.

作者信息

Calista D, Boschini A, Landi G

机构信息

Dermatology Unit "M. Bufalini" Hospital, 47023 Cesena, Italy.

出版信息

Eur J Dermatol. 1999 Apr-May;9(3):211-3.

PMID:10210787
Abstract

Molluscum contagiosum (MC), a cutaneous infection caused by a DNA virus belonging to the poxvirus group, affects about 5-10% of patients with HIV disease, often showing extensive, severe lesions, unresponsive to therapy [1]. During the follow-up of three patients with AIDS for MC recalcitrant to therapy, we noted their cutaneous lesions cleared 5-6 months after they had begun Highly Active Anti-Retroviral Therapy (HAART). This therapy includes an HIV protease inhibitor (indinavir) and two reverse transcriptase inhibitors [2, 3].

摘要

传染性软疣(MC)是由痘病毒科的一种DNA病毒引起的皮肤感染,约5%-10%的艾滋病患者会感染,常表现为广泛、严重的皮损,且对治疗无反应[1]。在对3例抗治疗性传染性软疣的艾滋病患者随访过程中,我们注意到他们在开始高效抗逆转录病毒治疗(HAART)5-6个月后,皮肤损害消退。该治疗包括一种HIV蛋白酶抑制剂(茚地那韦)和两种逆转录酶抑制剂[2, 3]。

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Resolution of disseminated molluscum contagiosum with Highly Active Anti-Retroviral Therapy (HAART) in patients with AIDS.艾滋病患者中高效抗逆转录病毒疗法(HAART)治疗播散性传染性软疣的疗效
Eur J Dermatol. 1999 Apr-May;9(3):211-3.
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引用本文的文献

1
HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management.抗逆转录病毒治疗时代的 HIV 相关皮肤疾病:识别与管理。
Am J Clin Dermatol. 2019 Jun;20(3):423-442. doi: 10.1007/s40257-019-00422-0.
2
A novel target and approach for identifying antivirals against molluscum contagiosum virus.一种用于鉴定抗传染性软疣病毒抗病毒药物的新靶点和方法。
Antimicrob Agents Chemother. 2014 Dec;58(12):7383-9. doi: 10.1128/AAC.03660-14. Epub 2014 Sep 29.
3
Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod.
一名HIV阳性儿童的播散性传染性软疣。5%咪喹莫特治疗后病情改善。
J Dermatol Case Rep. 2011 Jun 6;5(2):19-23. doi: 10.3315/jdcr.2011.1066.
4
Disfiguring molluscum contagiosum in a HIV-positive patient responding to antiretroviral therapy.一名接受抗逆转录病毒治疗且病情好转的HIV阳性患者身上出现毁容性传染性软疣。
Indian J Dermatol. 2009;54(2):180-2. doi: 10.4103/0019-5154.53188.