Walling Hobart W, Messingham Michael, Myers Laura M, Mason Camille L, Strauss John S
Department of Dermatology, University of Iowa, Iowa City, Iowa 52242, USA.
J Drugs Dermatol. 2003 Dec;2(6):677-81.
Acanthosis nigricans (AN) is an eruption of hyperpigmented, velvety thickened patches, often with papillomatosis, that occurs symmetrically on any body site but most commonly at the axillae, neck, groin, and flexural surfaces. We report a case of a 55-year-old obese male who developed acanthosis nigricans with striking papillomatosis and tripe palms who experienced improvement on a long-term tapering dosage of isotretinoin, with additional benefit with the addition of metformin. While oral retinoids have been reported to positively impact AN, improvement of AN with metformin has been reported in only two prior cases. Combined therapy with isotretinoin and metformin for AN has not been reported previously.
黑棘皮病（AN）是一种色素沉着过度、天鹅绒样增厚斑块的皮疹，常伴有乳头瘤病，对称发生于身体任何部位，但最常见于腋窝、颈部、腹股沟和屈侧表面。我们报告一例55岁肥胖男性，患有伴有显著乳头瘤病和掌纹症的黑棘皮病，长期逐渐减量服用异维A酸后病情改善，加用二甲双胍后获益更多。虽然有报道称口服维甲酸对黑棘皮病有积极影响，但此前仅有两例报告显示二甲双胍可改善黑棘皮病。异维A酸和二甲双胍联合治疗黑棘皮病此前尚未见报道。
