Guo Hangyuan, Lee Jong-Dae, Ueda Takanori, Shan Jiang, Wang Jian'an
Department of Cardiology, Medical College, Zhejiang University, Hangzhou, China.
Jpn Heart J. 2003 Nov;44(6):865-71. doi: 10.1536/jhj.44.865.
The aim of this study was to study the relationship between plasma homocysteine (Hcy), folic acid, vitamin B12 and early coronary artery disease (early-CAD) and high coronary risk factors. The plasma Hcy levels of 58 cases with early-CAD and 31 subjects without CAD were measured using high-performance liquid chromatography (HPLC) with fluorescence detection. Plasma folic acid and Vitamin B12 levels were measured with radioassay method. The plasma Hcy level was significantly higher in the early-CAD patients than in the controls [(13.7 +/- 5.1) micromol/L vs (10.3 +/- 5.7) micromol/L]. The plasma folic acid and Vitamin B12 levels were significantly lower in the early-CAD patients than in the controls. The plasma Hcy level was higher in patients with more than 3 risk factors of CAD than in patients with 1 or 2 risk factors and in the controls [(17.3 +/- 5.1) micromol/ L vs (12.9 +/- 4.8) micromol/L, (7.8 +/- 2.5) micromol/L]. Other than gender, all classical coronary risk factors were related to the elevated Hcy level. Hcy levels were elevated in patients with early-CAD and with high risk factors. Hyperhomocysteinemia plays an important role in the pathogenesis of CAD.
本研究旨在探讨血浆同型半胱氨酸（Hcy）、叶酸、维生素B12与早期冠状动脉疾病（early-CAD）及高冠状动脉风险因素之间的关系。采用高效液相色谱法（HPLC）结合荧光检测，测定了58例早期CAD患者和31例无CAD受试者的血浆Hcy水平。采用放射免疫法测定血浆叶酸和维生素B12水平。早期CAD患者的血浆Hcy水平显著高于对照组[（13.7±5.1）μmol/L对（10.3±5.7）μmol/L]。早期CAD患者的血浆叶酸和维生素B12水平显著低于对照组。CAD风险因素超过3个的患者血浆Hcy水平高于有1或2个风险因素的患者及对照组[（17.3±5.1）μmol/L对（12.9±4.8）μmol/L，（7.8±2.5）μmol/L]。除性别外，所有经典的冠状动脉风险因素均与Hcy水平升高有关。早期CAD患者及高风险因素患者的Hcy水平升高。高同型半胱氨酸血症在CAD发病机制中起重要作用。
