Ma Yan, Peng Duanliang, Liu Chenggui, Huang Chen, Luo Jun
East Branch, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No. 585 Hong He North Road, Longquan District, Chengdu, 610101, China.
Department of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, Chongqing Medical University, No. 1617 Ri Yue Avenue, Qingyang District, Chengdu, 610091, China.
BMC Cardiovasc Disord. 2017 Jan 21;17(1):37. doi: 10.1186/s12872-017-0475-8.
Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B are two vital regulators in Hcy metabolic process. We evaluated the correlations between serum Hcy, folic acid and vitamin B with the categories of CAD.
Serum Hcy, folic acid and vitamin B from 292 CAD patients, including 73 acute myocardial infarction (AMI), 116 unstable angina pectoris (UAP), 103 stable angina pectoris (SAP), and 100 controls with chest pain patients were measured, and the data were analyzed by SPSS software.
Compared to SAP patients, patients with AMI and UAP had higher Hcy levels with approximately average elevated (4-5) μmol/L, while SAP patients were approximately higher 8 μmol/L than controls. However, the levels of folic acid and vitamin B had opposite results, which in AMI group was the lowest, while in controls was the highest. CAD categories were positively correlated with Hcy (r = 0.286, p < 0.001), and negatively correlated with folic acid (r = -0.297, p < 0.001) and vitamin B (r = -0.208, p < 0.001). There were significant trend toward increase in the prevalence of high Hcy, low folic acid and vitamin B from controls, to SAP, to UAP, and to AMI.
The present study provide the valuable evidence that high concentrations of Hcy and low levels of folic acid and vitamin B are significantly correlated with CAD categories.
同型半胱氨酸（Hcy）被认为是冠状动脉疾病（CAD）的一个独立危险因素。叶酸和维生素B是Hcy代谢过程中的两个重要调节因子。我们评估了血清Hcy、叶酸和维生素B与CAD类别之间的相关性。
测量了292例CAD患者的血清Hcy、叶酸和维生素B，其中包括73例急性心肌梗死（AMI）、116例不稳定型心绞痛（UAP）、103例稳定型心绞痛（SAP），以及100例胸痛对照患者，并使用SPSS软件对数据进行分析。
与SAP患者相比，AMI和UAP患者的Hcy水平更高，平均升高约（4 - 5）μmol/L，而SAP患者比对照组高约8 μmol/L。然而，叶酸和维生素B的水平结果相反，AMI组最低，对照组最高。CAD类别与Hcy呈正相关（r = 0.286，p < 0.001），与叶酸呈负相关（r = -0.297，p < 0.001），与维生素B呈负相关（r = -0.208，p < 0.001）。从对照组到SAP、UAP再到AMI，高Hcy、低叶酸和低维生素B的患病率有显著上升趋势。
本研究提供了有价值的证据，即高浓度的Hcy和低水平的叶酸及维生素B与CAD类别显著相关。
