Miranda Pedro O, Estévez Francisco, Quintana José, García Candelaria I, Brouard Ignacio, Padrón Juan I, Pivel Juan P, Bermejo Jaime
Instituto Universitario de Bio-Orgánica Antonio González-Instituto de Productos Naturales y Agrobiología-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain.
J Med Chem. 2004 Jan 15;47(2):292-5. doi: 10.1021/jm034216y.
Compounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [(3)H]-PGE(2) binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE(2). Compound 9 increases c-fos mRNA level as does PGE(2) and antagonizes TPA-induced terminal differentiation.
