Brodskyn Cláudia, de Oliveira Camila I, Barral Aldina, Barral-Netto Manoel
Instituto de Ciências da Saúde- Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Expert Rev Vaccines. 2003 Oct;2(5):705-17. doi: 10.1586/14760584.2.5.705.
The leishmaniases are a group of diseases caused by protozoa of the genus Leishmania which affects millions of people worldwide. The leishmaniases are transmitted to the vertebrate hosts by phlebotomine sand flies. In this review, we focus on clinical aspects of the leishmaniases and on the immune response against the parasite, both in animal models and humans. These aspects are of key importance to understand the many attempts to obtain an effective vaccine against Leishmania. We considered the last advances in new generation vaccines, including the use of new adjuvants to improve the protective response against the parasite. Finally, the possibility to use components of the sand fly saliva as part of vaccines against the infection by Leishmania is mentioned.
利什曼病是由利什曼原虫属的原生动物引起的一组疾病，全球数百万人受其影响。利什曼病通过白蛉传播给脊椎动物宿主。在本综述中，我们重点关注利什曼病的临床方面以及在动物模型和人类中针对该寄生虫的免疫反应。这些方面对于理解为获得针对利什曼原虫的有效疫苗所做的诸多尝试至关重要。我们考虑了新一代疫苗的最新进展，包括使用新型佐剂来增强针对该寄生虫的保护性反应。最后，还提到了将白蛉唾液成分用作抗利什曼原虫感染疫苗一部分的可能性。
