Huygen Kris
Pasteur Institute of Brussels, Mycobacterial Immunology, 642 Engelandstraat, B1180 Brussels, Belgium.
Expert Rev Vaccines. 2003 Aug;2(4):561-9. doi: 10.1586/14760584.2.4.561.
Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buruli disease is transmitted by direct person-to-person contact and it is very likely that contaminated water of rivers, swamps and lakes serves as the wildlife reservoir of M. ulcerans. This review briefly discusses the epidemiology, microbiology, pathology and treatment of the disease. It describes in detail the current knowledge of the immune response and focuses on the studies that have dealt with vaccination. Finally, experimental approaches for future immunoprophylaxis are discussed.
由溃疡分枝杆菌引起的布鲁里病是热带地区，特别是西非出现的一种传染病，可导致深部坏死性皮肤病变，称为布鲁里溃疡。布鲁里病影响所有年龄组，但约50%的病例在儿童中被诊断出来。没有证据表明布鲁里病通过人与人之间的直接接触传播，很可能河流、沼泽和湖泊中受污染的水是溃疡分枝杆菌的野生动物宿主。本文简要讨论了该病的流行病学、微生物学、病理学和治疗方法。详细描述了目前对免疫反应的认识，并重点介绍了与疫苗接种相关的研究。最后，讨论了未来免疫预防的实验方法。
