Fernández Luis E, Alonso Daniel F, Gomez Daniel E, Vázquez Ana M
Center of Molecular Immunology, PO Box 16040, Havana 11600, Cuba.
Expert Rev Vaccines. 2003 Dec;2(6):817-23. doi: 10.1586/14760584.2.6.817.
This review shall present an update in anticancer ganglioside-based immunotherapies, with particular emphasis on molecular vaccines and anti-idiotype mAbs produced by the Center of Molecular Immunology (Havana, Cuba). The project comprises vaccines of N-acetyl or N-glycolylneuraminic acid GM3 ganglioside incorporated into very small proteoliposomes and anti-idiotype antibodies to glycolylated gangliosides. Development of these vaccine preparations from preclinical models of melanoma, breast and lung cancer to human investigation is summarized. A brief discussion on the progress and limitations of present-day clinical trials and future prospects is also included.
本综述将介绍基于抗癌神经节苷脂的免疫疗法的最新进展，特别强调分子疫苗和由分子免疫学中心（古巴哈瓦那）生产的抗独特型单克隆抗体。该项目包括将N-乙酰或N-糖基神经氨酸GM3神经节苷脂掺入非常小的蛋白脂质体中的疫苗，以及针对糖基化神经节苷脂的抗独特型抗体。总结了这些疫苗制剂从黑色素瘤、乳腺癌和肺癌的临床前模型到人体研究的开发过程。还包括对当前临床试验的进展和局限性以及未来前景的简要讨论。
