Salisbury Jeffrey L
Tumor Biology Program, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA.
Curr Biol. 2004 Jan 6;14(1):R27-9. doi: 10.1016/j.cub.2003.12.019.
The discovery of Sfi1p as a novel binding partner for the Ca2+-binding protein centrin has provided new insight into the dynamic behavior of centrosomes. Sfi1 binds to multiple centrin molecules along a series of internal repeats, and the complex forms Ca2+-sensitive contractile fibers that function to reorient centrioles and alter centrosome structure.
Sfi1p作为一种与钙结合蛋白中心蛋白的新型结合伴侣的发现，为中心体的动态行为提供了新的见解。Sfi1沿着一系列内部重复序列与多个中心蛋白分子结合，并且该复合物形成对钙敏感的收缩纤维，其功能是重新定向中心粒并改变中心体结构。
