Gambichler T, Paech V, Rotterdam S, Stücker M, Boms S, Altmeyer P
Dermatology Out-Patient Clinic, Oldchurch Hospital, Romford (Greater East London), United Kingdom.
Eur J Med Res. 2003 Dec 9;8(12):527-30.
Adult-onset Still's disease (AOSD) is an uncommon systemic inflammatory disorder that is characterized by quotidian fever, articular manifestations, neutrophilic leukocytosis, and maculopapular rash. The aetiology of the disease is unknown, however, an infectious cause has been suggested. Here we describe a patient in whom neutrophilic urticaria was the cutaneous manifestation of AOSD. In addition, the patient suffered from chronic hepatitis B infection that may be a potential trigger factor of AOSD. In patients with AOSD, serological investigations for detection of infection should include hepatitis serology. Further, we suggest that urticarial lesions may be a more common cutaneous manifestation of AOSD than has been recognized previously. Thus it is important to include AOSD in the differential diagnosis of urticaria.
成人斯蒂尔病（AOSD）是一种罕见的全身性炎症性疾病，其特征为每日发热、关节表现、中性粒细胞增多及斑丘疹。该病病因不明，但有人提出可能由感染引起。在此，我们描述了一名患者，其嗜中性荨麻疹是AOSD的皮肤表现。此外，该患者患有慢性乙型肝炎感染，这可能是AOSD的一个潜在触发因素。对于AOSD患者，检测感染的血清学检查应包括肝炎血清学检查。此外，我们认为荨麻疹性皮损可能是AOSD比以往认识到的更为常见的皮肤表现。因此，在荨麻疹的鉴别诊断中纳入AOSD很重要。
