对小鼠肝细胞氧化损伤的保护作用。
Protection from oxidative damage in mouse liver cells.
作者信息
Harman A W, Adamson G M, Shaw S G
机构信息
Department of Pharmacology, University of Western Australia, Nedlands.
出版信息
Toxicol Lett. 1992 Dec;64-65 Spec No:581-7. doi: 10.1016/0378-4274(92)90235-c.
PMID:1471211
Abstract
Paracetamol toxicity in mouse hepatocytes involved oxidative stress initiated by the formation of NAPQI. This oxidative component of paracetamol injury is associated with the latter stages of the poisoning process. Ebselen, a drug with GSH-peroxidase activity, was effective in ameliorating these oxidative events.
摘要
对乙酰氨基酚对小鼠肝细胞的毒性作用涉及由 N - 乙酰 - 对苯醌亚胺（NAPQI）形成引发的氧化应激。对乙酰氨基酚损伤的这种氧化成分与中毒过程的后期阶段相关。依布硒啉是一种具有谷胱甘肽过氧化物酶活性的药物，可有效改善这些氧化事件。
Zotero 插件