Luster M I, Pait D G, Portier C, Rosenthal G J, Germolec D R, Comment C E, Munson A E, White K, Pollock P
Systems Toxicity Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Toxicol Lett. 1992 Dec;64-65 Spec No:71-8. doi: 10.1016/0378-4274(92)90174-i.
We have previously reported on the design and content of a screening battery using a "tier" approach for detecting potential immunosuppressive compounds in mice [1]. This battery was composed of various immune function, immunopathology and host resistance tests, the results of which could help establish the potential of chemical and biological agents to cause immunosuppression. The data from these studies, which now encompass over 50 compounds, have been analyzed in an attempt to improve future testing strategies and provide information to aid in the risk assessment process. Specifically, the following two issues will be addressed; what are the likelihood(s) for each of the individual tests and testing configurations to accurately identify immunotoxic compounds? and what are the quantitative and qualitative relationships between the immune tests and host resistance assays?
我们之前曾报道过一种使用“分层”方法的筛选组合，用于在小鼠中检测潜在的免疫抑制化合物的设计和内容[1]。该组合由各种免疫功能、免疫病理学和宿主抵抗力测试组成，其结果有助于确定化学和生物制剂导致免疫抑制的可能性。这些研究的数据（目前已涵盖50多种化合物）已进行分析，以尝试改进未来的测试策略，并提供有助于风险评估过程的信息。具体而言，将解决以下两个问题：各个单独测试和测试组合准确识别免疫毒性化合物的可能性有多大？免疫测试与宿主抵抗力测定之间的定量和定性关系是什么？
