Luster M I, Portier C, Pait D G, Germolec D R
Environmental Immunology and Neurobiology Section, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709.
Toxicology. 1994 Sep 6;92(1-3):229-43. doi: 10.1016/0300-483x(94)90180-5.
We have previously reported on the design and content of a screening battery involving a 'tier' approach for detecting potential immunosuppressive compounds in mice. This battery has been used to examine a variety of compounds, and the database generated from these studies, which consists of over 50 compounds, has been collected and analyzed in an attempt to improve the accuracy and efficiency of screening chemicals for immunosuppression and to identify better those tests that predict experimentally-induced, immune-mediated diseases. Specifically, these analyses attempted to develop an improved testing configuration for the accurate prediction of immunotoxic agents and to provide insight into the qualitative and quantitative relationships between a number of immune and host resistance assays commonly employed to examine potential immunotoxic chemicals in experimental animals. While a number of limitations existed in the analyses, several conclusions were drawn from the results which will be discussed.
我们之前曾报道过一种筛选组合的设计和内容，该组合采用“分层”方法来检测小鼠体内潜在的免疫抑制化合物。这个组合已被用于检测多种化合物，并且从这些研究中生成的数据库（包含50多种化合物）已被收集和分析，目的是提高筛选化学物质免疫抑制作用的准确性和效率，并更好地识别那些能预测实验诱导的免疫介导疾病的测试。具体而言，这些分析试图开发一种改进的测试配置，以准确预测免疫毒性剂，并深入了解在实验动物中用于检测潜在免疫毒性化学物质的一些免疫和宿主抵抗力测定之间的定性和定量关系。虽然分析存在一些局限性，但从结果中得出了一些结论，将在下文进行讨论。
