对乙酰氨基酚每日滥用患者的血浆谷胱甘肽水平。给予还原型谷胱甘肽后血浆半胱氨酸和巯基的变化。

Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration.

作者信息

Trenti T, Bertolotti M, Castellana C N, Ferrari A, Pini L A, Sternieri E

机构信息

Toxicology and Clinical Pharmacology Service, Policlinico, Modena, Italy.

出版信息

Toxicol Lett. 1992 Dec;64-65 Spec No:757-61. doi: 10.1016/0378-4274(92)90258-l.

DOI:10.1016/0378-4274(92)90258-l

PMID:1471232

Abstract

Since plasma reduced glutathione (GSH) seems to reflect liver GSH content, we have assessed plasma GSH in patients using paracetamol daily. In these patients a significant lower plasma GSH concentration was found with respect to controls. After the i.v. administration of GSH free plasma cysteine was 12 fold higher than in basal condition and all the pattern of plasma thiol groups was modified. This work suggests that the possible protective effect of GSH administration is due to the availability of plasma thiol compounds that enter the cell rather than GSH itself.

摘要

由于血浆还原型谷胱甘肽（GSH）似乎反映了肝脏中的GSH含量，我们评估了每日服用对乙酰氨基酚患者的血浆GSH水平。与对照组相比，这些患者的血浆GSH浓度显著降低。静脉注射GSH后，游离血浆半胱氨酸比基础状态下高12倍，并且血浆硫醇基团的所有模式都发生了改变。这项研究表明，给予GSH可能的保护作用是由于进入细胞的血浆硫醇化合物的可用性，而不是GSH本身。