Dodziuk Helena, Koźmiński Wiktor, Ejchart Andrzej
Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Chirality. 2004 Feb;16(2):90-105. doi: 10.1002/chir.10304.
Chiral recognition by cyclodextrins is of considerable importance, especially for pharmaceutical industry, in view of the possible side effects of the second enantiometer of chiral drugs. In general, it manifests itself in all NMR parameters (chemical shifts, coupling constants, NOE and ROE effects, and relaxation rates) on one hand. On the other hand, it allows one to determine the thermodynamic parameters characterizing diastereomeric complexes formed by cyclodextrins with enantiomeric guests. After an introduction and a general discussion of NMR manifestations of chiral recognition by cyclodextrin, the existing literature data on this problem will be discussed herein. Chirality 16:90-105, 2004.
鉴于手性药物的对映体可能存在副作用，环糊精的手性识别具有相当重要的意义，尤其对于制药行业而言。一般来说，它一方面体现在所有核磁共振参数（化学位移、耦合常数、核Overhauser效应和旋转Overhauser效应以及弛豫速率）上。另一方面，它使人们能够确定表征环糊精与对映体客体形成的非对映体复合物的热力学参数。在对环糊精手性识别的核磁共振表现进行介绍和一般性讨论之后，本文将讨论关于这个问题的现有文献数据。《手性》第16卷：90 - 105页，2004年。
