2-（2,3-二氢-1H-吲哚-3-基）乙醇：对映体的合成、分离及通过X射线结构分析确定绝对立体化学构型
2-(2,3-Dihydro-1H-indol-3-yl)ethanol: synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis.
作者信息
Frydenvang Karla, Sommer Michael Bech, Heckmann Dieter, Nielsen Ole, Bang-Andersen Benny
机构信息
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark.
出版信息
Chirality. 2004 Feb;16(2):126-30. doi: 10.1002/chir.10313.
The first direct resolution of racemic 2-(2,3-dihydro-lH-indol-3-yl)ethanol-prepared by catalytic hydrogenation of 2-(lH-indol-3-yl)ethanol-has been accomplished by chiral simulated moving bed (SMB) chromatography. The single enantiomers were isolated as their dihydrogen phosphate salts. Single-crystal X-ray analyses were successful, revealing that the (+)-enantiomer of 2-(2,3-dihydro-lH-indol-3-yl)ethanol has the (S) configuration. Chirality 16:126-130, 2004.
通过手性模拟移动床（SMB）色谱法首次直接拆分了通过2-（1H-吲哚-3-基）乙醇催化氢化制备的外消旋2-（2,3-二氢-1H-吲哚-3-基）乙醇。将单一对映体分离为它们的磷酸二氢盐。单晶X射线分析成功，表明2-（2,3-二氢-1H-吲哚-3-基）乙醇的（+）-对映体具有（S）构型。《手性》，2004年，第16卷，第126 - 130页。
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