Aitken A, Collinge D B, van Heusden B P, Isobe T, Roseboom P H, Rosenfeld G, Soll J
Laboratory of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK.
Trends Biochem Sci. 1992 Dec;17(12):498-501. doi: 10.1016/0968-0004(92)90339-b.
A family of proteins known as 14-3-3 is currently receiving increased attention by investigators studying a broad range of biological systems, including plants and invertebrates. The outstanding feature of this family is the extraordinarily high sequence conservation observed. Current thinking indicates that these proteins may function as regulators in signal transduction/phosphorylation mechanisms.
目前，一类名为14-3-3的蛋白质家族正受到研究包括植物和无脊椎动物在内的广泛生物系统的研究人员越来越多的关注。该家族的显著特征是观察到的极高的序列保守性。目前的观点认为，这些蛋白质可能在信号转导/磷酸化机制中作为调节因子发挥作用。
