秋水仙碱诱发的慢性心力衰竭患者横纹肌溶解症

Colchicine-induced rhabdomyolysis in a patient with chronic heart failure.

作者信息

Debie Karen, Conraads Viviane, Vrints Christiaan

机构信息

Department of Cardiology, University Hospital Antwerp, Edegem, Belgium.

出版信息

Acta Cardiol. 2003 Dec;58(6):561-2. doi: 10.2143/AC.58.6.2005322.

DOI:10.2143/AC.58.6.2005322

PMID:14713183

Abstract

Gout is a common co-morbidity in patients with chronic heart failure and its treatment is complex. We report the case of a 58-year-old man with chronic severe heart failure who developed rhabdomyolisis after short-term intake of colchicine. Although colchicine is a highly effective therapy for acute gouty arthritis, the dosage should be carefully titrated in patients with chronic heart failure, especially if renal or liver disease are also present.

摘要

痛风是慢性心力衰竭患者常见的合并症，其治疗较为复杂。我们报告一例58岁慢性重度心力衰竭男性患者，在短期服用秋水仙碱后发生横纹肌溶解症。尽管秋水仙碱是治疗急性痛风性关节炎的高效药物，但对于慢性心力衰竭患者，尤其是同时存在肾脏或肝脏疾病的患者，用药剂量应谨慎滴定。