Miyamoto Shinzo, Kawano Hiroaki, Sakamoto Tomohiro, Soejima Hirofumi, Kajiwara Ichiro, Hokamaki Jun, Hirai Nobutaka, Sugiyama Seigo, Yoshimura Michihiro, Yasue Hirofumi, Nakamura Hajime, Yodoi Junji, Ogawa Hisao
Antioxid Redox Signal. 2004 Feb;6(1):75-80. doi: 10.1089/152308604771978363.
To determine whether plasma levels of thioredoxin are associated with coronary spasm, we measured the plasma levels of thioredoxin in 170 patients who had <25% organic stenosis in coronary arteriography. According to the results of cardiac catheterization, we divided the patients into two groups: a coronary spastic angina group (n=84) and a chest pain syndrome group (n=86). The plasma levels of thioredoxin were significantly higher in the coronary spastic angina group than in the chest pain syndrome group (40.7 +/- 4.1 versus 18.2 +/- 1.1 ng/ml, p<0.0001). Furthermore, the increased plasma levels of thioredoxin were associated with high disease activity indicated by the frequency of angina attacks (p=0.0004). In multiple logistic regression analysis, the higher levels of thioredoxin [relative risk 14.8, 95% confidence interval (5.13-42.9), p<0.0001] and current smoking [relative risk 3.39, 95% confidence interval (1.31-8.75), p=0.012] were significant and independent variables associated with coronary spasm. We demonstrated that the plasma levels of thioredoxin were increased in the coronary spastic angina group, and increased levels of thioredoxin were associated with high disease activity. The plasma levels of thioredoxin and current smoking were risk factors for coronary spastic angina, and they were independent from other traditional risk factors.
为了确定血浆硫氧还蛋白水平是否与冠状动脉痉挛有关，我们测量了170例冠状动脉造影显示有机狭窄<25%的患者的血浆硫氧还蛋白水平。根据心脏导管检查结果，我们将患者分为两组：冠状动脉痉挛性心绞痛组（n = 84）和胸痛综合征组（n = 86）。冠状动脉痉挛性心绞痛组的血浆硫氧还蛋白水平显著高于胸痛综合征组（40.7±4.1对18.2±1.1 ng/ml，p<0.0001）。此外，血浆硫氧还蛋白水平的升高与心绞痛发作频率所表明的高疾病活动度相关（p = 0.0004）。在多因素逻辑回归分析中，硫氧还蛋白水平较高[相对风险14.8，95%置信区间（5.13 - 42.9），p<0.0001]和当前吸烟[相对风险3.39，95%置信区间（1.31 - 8.75），p = 0.012]是与冠状动脉痉挛相关的显著且独立的变量。我们证明冠状动脉痉挛性心绞痛组的血浆硫氧还蛋白水平升高，且硫氧还蛋白水平升高与高疾病活动度相关。血浆硫氧还蛋白水平和当前吸烟是冠状动脉痉挛性心绞痛的危险因素，且它们独立于其他传统危险因素。
