Pahimi Nurnajwa, Rasool Aida Hanum Ghulam, Sanip Zulkefli, Bokti Nur Adilah, Yusof Zurkurnai, W Isa W Yus Haniff
Pharmacology Vascular Laboratory, Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia.
Cardiology Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia.
J Cardiovasc Dev Dis. 2022 Feb 4;9(2):51. doi: 10.3390/jcdd9020051.
Approximately half of all women presenting to the emergency department with angina chest pain do not have obstructive coronary artery disease (CAD) on coronary angiography. This condition is termed non-obstructive coronary artery disease (NOCAD), and includes ischemia with no obstructive coronary artery disease (INOCA) and myocardial infarction with non-obstructive coronary arteries (MINOCA). Oxidative stress has been reported to be involved in the development and progression of CAD. However, a scarcity of studies has assessed a correlation between oxidative stress and NOCAD. Thus, a literature review was performed of available reports on the role of oxidative stress in NOCAD. Possible mechanisms involved in oxidative stress that may contribute to NOCAD were identified and evaluated. A key finding of this literature review was that oxidative stress caused vasoconstriction and endothelial damage, and this results in coronary microvascular dysfunction and vasospasm, which, in turn, lead to the pathogenesis of NOCAD.
因心绞痛胸痛到急诊科就诊的女性中，约有一半在冠状动脉造影检查时没有阻塞性冠状动脉疾病（CAD）。这种情况被称为非阻塞性冠状动脉疾病（NOCAD），包括无阻塞性冠状动脉疾病的缺血（INOCA）和非阻塞性冠状动脉的心肌梗死（MINOCA）。据报道，氧化应激参与了CAD的发生和发展。然而，评估氧化应激与NOCAD之间相关性的研究较少。因此，对现有关于氧化应激在NOCAD中的作用的报告进行了文献综述。确定并评估了氧化应激可能导致NOCAD的潜在机制。这篇文献综述的一个关键发现是，氧化应激会导致血管收缩和内皮损伤，进而导致冠状动脉微血管功能障碍和血管痉挛，从而引发NOCAD的发病机制。
