Seamons Audrey, Perchellet Antoine, Goverman Joan
Department of Genome Sciences, University of Washington, Seattle, WA 98125, USA.
Immunol Res. 2003;28(3):201-21. doi: 10.1385/IR:28:3:201.
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system. It is believed to be an autoimmune disease arising from a breakdown of immune tolerance in T cells specific for myelin antigens. The heterogeneity in clinical signs and pathology observed in MS patients suggests a complex pathogenesis in which the specificity of the pathogenic T cells and the tolerance mechanisms that are compromised vary among individual patients. In this review, we summarize some of the features of the diverse immune pathology observed in MS and the animal models used to study this disease. We then describe the current state of knowledge regarding the expression of the major myelin protein antigens believed to be targeted in MS and the mechanisms of immune tolerance that operate on T cells that recognize these antigens.
多发性硬化症（MS）是一种中枢神经系统的脱髓鞘疾病。它被认为是一种自身免疫性疾病，由针对髓鞘抗原的T细胞免疫耐受破坏引起。MS患者临床症状和病理学的异质性表明其发病机制复杂，其中致病T细胞的特异性以及受损的耐受机制在个体患者之间存在差异。在本综述中，我们总结了MS中观察到的多种免疫病理学特征以及用于研究该疾病的动物模型。然后，我们描述了目前关于MS中被认为是靶向的主要髓鞘蛋白抗原的表达以及作用于识别这些抗原的T细胞的免疫耐受机制的知识状态。
