Schoenberg M H, Büchler M, Beger H G
Abteilung für Allgemeine Chirurgie, Universität Ulm, Bundesrepublik Deutschland.
Z Gastroenterol. 1992 Nov;30(11):801-7.
Oxygen-derived free radicals mediate an important step in the initiation of experimental acute pancreatitis. Thereby these reactive oxygen metabolites are generated at an early stage of disease. The source of the enhanced production of oxygen radicals remains unclear. Experimentally, the efficiency of scavenger treatment varied between different models, whereby these differences were depending on the experimental model and not on the form of pancreatitis which was induced. Most studies pretreated the experimental animals before inducing acute pancreatitis. This does not mirror the clinical reality, since patients are admitted to the hospital after onset of the disease. It was shown in Cerulein-pancreatitis, however, that scavenger treatment also mitigated the pancreatic tissue damages after induction of acute pancreatitis. Moreover, antioxidant treatment also attenuated the extrapancreatic complications, thus improving the final outcome of the disease. The first indirect observations also suggest that in human acute recurrent and chronic pancreatitis oxygen free radicals are generated and add to the damages seen. Therefore, well-defined controlled clinical studies with patients suffering from acute pancreatitis are needed to validate the role of oxygen radicals in this disease.
氧衍生的自由基在实验性急性胰腺炎的起始过程中介导了重要步骤。因此，这些活性氧代谢产物在疾病早期产生。氧自由基产生增加的来源尚不清楚。在实验中，清除剂治疗的效果在不同模型之间有所不同，这些差异取决于实验模型，而非所诱导的胰腺炎形式。大多数研究在诱导急性胰腺炎之前对实验动物进行预处理。这并不反映临床实际情况，因为患者是在疾病发作后才入院的。然而，在蛙皮素诱导的胰腺炎中发现，清除剂治疗在急性胰腺炎诱导后也减轻了胰腺组织损伤。此外，抗氧化剂治疗还减轻了胰腺外并发症，从而改善了疾病的最终结局。最初的间接观察结果还表明，在人类急性复发性胰腺炎和慢性胰腺炎中会产生氧自由基，并加重所见的损伤。因此，需要对急性胰腺炎患者进行明确的对照临床研究，以验证氧自由基在这种疾病中的作用。
